About anemia of kidney disease, how much do you know?

1.Erythropoietin (EPO) deficiency, EPO about 90% is synthesized by renal tubular mediators, uremic patients due to renal fibrosis, EPO synthesis was significantly reduced, the vast majority of patients with EPO deficiency.

2.Iron and vitamin deficiency dialysis patients due to poor appetite and other reasons, resulting in reduced iron intake, there is a significant lack of iron, and the patient has a significant inflammatory state, increased oxidative stress, resulting in iron use disorders, increased iron deficiency status. In addition, a large number of vitamins lost in dialysis, lack of supplement, can also cause the lack of hematopoietic raw materials.

3.Secondary hyperparathyroidism, is due to dialysis patients with calcium and phosphorus metabolism disorders, secondary hyperparathyroidism, hypercapnia iPTH on the formation of red blood cells inhibit the role. The rise of iPTH caused the disorder of bone metabolism, so that the microenvironment of bone marrow hematopoietic changes, hematopoietic stem cell activation was inhibited, erythropoiesis decreased.

4.Dialysis is not sufficient, blood loss, autoimmune diseases and other reasons will increase anemia. Anemia Clinical manifestations of symptoms: mild anemia is usually no obvious symptoms. When anemia is aggravated, it is often manifested as fatigue, difficulty breathing, and other symptoms include difficulty concentrating, dizziness, sleep disorders, chills and headaches. The above symptoms are slow, the body can be compensated. Severe anemia, the heart output increased significantly, there may be palpitations, physical decline and left ventricular hypertrophy. Some patients with hemostatic function, immune function, sexual function and cognitive ability to decline at the same time.