Five functions of erythropoietin

Erythropoietin is a glycoprotein hormone that stimulates bone marrow hematopoiesis , is a sialic acid containing acidic protein . In the traditional understanding , EPO is an endocrine hormone that acts on myeloid hematopoietic cells and promotes the proliferation , differentiation and maturation of erythroid progenitor cells , and plays an important regulatory role on oxygen supply to the body . With the deepening of research in recent years , EPO can also show non-erythropoirtic effect . Studies have shown that erythropoirtic in addition to regulating red blood cell production to increase tissue oxygen , also has antioxidant , anti-apoptotic , anti-inflammatory and promote angiogenesis , in the protection of liver ischemia-reperfusion injury has a certain biological mechanism .

1. Clear free radicals , anti-oxidation

The production of oxygen free radicals is one of the important mechanisms of liver IRI . Neutrophils adhere to endothelial cells , respiratory burst produce large amounts of oxygen free radicals , it not only causes endothelial cell-mediated vasodilation dysfunction , but also has a strong chemotactic effect on inflammatory cells , further aggravate the vicious circle of inflammatory reaction process , finallu lead to cardiovascular and other vital organs and other functions of the serious injury .  

2. Reduce calcium overload

Studies have shown that EPO can play a role by regulating Ca2+ influx . When EPO and EPOR combined , EPOR is activated and directly acts on the Ca2+ channel , inhibition of Ca2+ influx by depolarization reduced the damage of nerve cells by glutamate released by synaptic vesicles .

3. Anti-apoptotic effect

Apoptosis is programmed death under certain pathophysiological conditions and plays an important role in various injuries . Research shows that EPO is an anti-apoptotic factor , can inhibit the occurrence of vascular endothelial factor apoptosis , stimulate endothelial cell precursor mitosis , induces the production of cell-mediated matrix metalloproteinase-2 and promotes the formation of blood vessels .

4. Anti-inflammatory effect

EPO can reduce the release of many inflammatory cytokines , reduce the infiltration of inflammatory cells and thus play an important anti-inflammatory effect .

5. Promote the role of angiogenesis

Maintaining vascular structure and function plays an important role in the repair of various injuries .

Specific dosage , please leave a message symptoms and contact information , we will provide you with specific programs according to your situation .