The renal survival of patients with IgA nephropathy has been improved

Hematuria is the main symptom of IgA nephropathy, but its effect on the risk of disease progression is not clear.

Recently, the field of kidney disease authoritative Journal of the American Society of Nephrology published a study, researchers followed 112 patients with IgA nephropathy, follow-up time mean + / - standard deviation for 14 + / - 10.2 years, during the follow-up period regularly recorded the clinical and scientific analysis of risk factors (including urinary sediment examination).

According to the average amount of blood urine, the researchers divided the patients into persistent hematuria and negative or mild hematuria.

The researchers also classified the patients by the average time of their urine protein levels (> 0.75 or less than 0.75 g/d).

The researchers found that the proportion of patients with persistent hematuria progression to end-stage renal disease or renal function decline was significantly higher than those in the blood test group (30.4% versus 37% vs. 10.6% and 15.2%, P = 0.01).

Multivariate analysis showed that the average hematuria, time average albuminuria, basic renal function and renal biopsy were independent predictors of end-stage renal disease.

After the hematuria of 46 percent of the patients disappeared, the renal function decreased from -6.45 to 0.18, or 0.18, or minus 2.56ml/min/1.73m2 (P = 0.001).

Average time of urine protein > 0.75 g/d renal survival rate of patients significantly poorer, compared to the time average patients with urinary protein 0.75 g/d or less, but for the time average of the blood in the urine further classification, with the passage of time, only the time average urine protein > 0.75 g/d and persistent hematuria patients with poor kidney survival rate, compared with the other three groups.

Thus, relieving hematuria may have a better effect on the prognosis of IgA nephropathy.