Why is nephrotic syndrome bloated?

Core tip: plasma offshoring moisture reduce effective blood volume, which led to the following changes in the body: by volume receptor increase antidiuretic hormone (ADH), renal tubular reabsorption more water;

By stimulating renin - angiotensin - aldosterone system, secondary aldosteronism was produced, so that the renal tubule increased sodium reabsorption;

Inhibits the production of the sodium factor and reduces the sodium discharge.

The water in the body, the sodium retention, further aggravate the edema.

The cause of high edema of nephrotic syndrome is:

(1) reduction of the osmotic pressure of plasma colloids: the exchange of bodily fluids in and out of blood vessels is regulated by osmotic pressure on both sides.

Osmotic pressure including crystal osmotic pressure and colloid osmotic pressure, the former from crystal material (mainly the electrolyte), because of its free through the capillary wall, so not much effect on vascular fluid exchange inside and outside;

The latter mainly comes from protein (mainly albumin), because it cannot freely pass through the capillary wall, which is the main factor in the exchange of fluids inside and outside the blood vessels.

Nephrotic syndrome is caused by the loss of a large amount of plasma protein from the urine, resulting in hypoalbuminemia, resulting in decreased osmotic pressure in the plasma colloid, when it is normally 3.

3 ~ 4kPa fell to 0.

8 to 1.

At 1kPa, the fluid in the blood vessels moved to the hypertonic interstitial fluid, and the edema occurred.

(2) the effective blood volume reduction: plasma offshoring moisture reduce effective blood volume, which led to the following changes in the body: by volume receptor increase antidiuretic hormone (ADH), renal tubular reabsorption more water;

By stimulating renin - angiotensin - aldosterone system, secondary aldosteronism was produced, so that the renal tubule increased sodium reabsorption;

Inhibits the production of the sodium factor and reduces the sodium discharge.

The water in the body, the sodium retention, further aggravate the edema.

The above two factors together cause nephrotic syndrome height dropsy.