Three truths about uric acid high!

Uric acid is high, and the harm is not just gout

In many people's impression, the danger of uric acid is gout.

As long as there is no development for gout, blood uric acid is high.

However, several clinical studies have found that hyperuricemia is not only a cause of gout, but also associated with multiple diseases.

Hyperuricemia is an important problem for the physical health of middle-aged and elderly people, which is equivalent to high blood pressure and diabetes.

A large number of clinical studies have shown that high uric acid hematic disease and cardiovascular disease, endocrine disease and chronic kidney disease are closely related, are independent risk factors for these diseases occurrence and development.

In other words, gout is only the tip of the iceberg caused by hyperuricemia.

The study found that the risk of new diabetes increased by 17 per cent for every 60 micromol/litre increase in serum uric acid levels.

The risk of hypertension in patients with hyperuricemia increased by 81 per cent, and the blood uric acid increased by 9 per cent.

High uric acid hematic disease had a 9% increased risk of coronary heart disease patients occurred, coronary heart disease death risk by 16%, and the blood uric acid increase 60 micro mo/liter, coronary heart disease death risk by 12%, especially female patients;

The risk of stroke in patients with hyperuricemia increased by 22 per cent and the risk of stroke increased by 33 per cent.

Hyperuricemia is more direct and obvious damage to the kidneys, because in normal conditions, about 70% of uric acid is discharged through the kidneys.

The occurrence and progress of hyperuricemia are closely related to the development of acute and chronic nephropathy. They interact and influence each other, and there is a certain causality.

Hyperuricemia can lead to acute uric acid nephropathy and chronic uric acid nephropathy, and even renal failure.

In patients with chronic nephropathy, the decrease of renal function and uric acid excretion will further aggravate hyperuricemia.

The study found that the risk of acute renal failure increased by 74% for every 60 micromo/liter of blood uric acid.

In patients with >392 microbe, the risk of chronic renal failure occurred, with the increase of 94% in men and 420% in women, indicating that the blood uric acid level was significantly correlated with the incidence of chronic renal failure, especially in women.

In addition, foreign reports indicate that patients with hyperuricemia are more likely to have severe liver injury in patients with non-alcoholic fatty liver disease.

It is also reported that hyperuricemia is more likely to improve serum alanine aminotransferase (ALT) levels for obese adolescents.

"Diuretic acid", "tulip" effect is limited

In the impression of many people, once the gout, must control the mouth, big fish meat not to eat, must eat light.

However, to reduce uric acid, "tubule mouth" really useful?

The answer is no.

Gout is closely related to uric acid and uric acid is a product of purine metabolism.

Human metabolism produces purines, and purines are ingested from food, and uric acid occurs after purine metabolism.

Uric acid in the blood, 20 percent from food, 80 percent from the body's metabolism.

That is to say, only by "the mouth", limiting the intake of purines to reduce uric acid, the effect is very limited, because only 20% of uric acid comes from food.

On the other hand, in normal conditions, uric acid is excreted from the urine by the kidneys.

If you have too much purine, you'll get more uric acid, and once the human body doesn't get rid of uric acid, uric acid will accumulate in your body.

Studies have found that the cause of hyperuricemia, "increased generation" only accounts for 10%, and "excretion disorder" accounts for 90%.

In this situation, the effect of restricting the intake of purine foods is more limited.

"Uric acid is high", "promoting excretion" is the key

To reduce further damage to the body, patients need to take medication to lower their levels of uric acid.

There are two commonly used drugs, one is to reduce uric acid synthesis, such as other than urinol, etc.

Another is drugs that promote uric acid excretion, such as benzbromolone.

As a result of the cause of hyperuricemia, the excretion disorder accounts for 90%, so strengthening uric acid excretion is the key to treatment.

It is worth noting that there are studies that show that the levels of uric acid in the blood of overweight people tend to be high, and the blood uric acid levels can be significantly reduced after weight loss.

Therefore, exercise weight loss can help reduce uric acid content and prevent gout.

However, when gout attacks, be sure to avoid exercise and raise your legs, and properly ice compress for the affected area.